MPO-ANCA–Positive Eosinophilic Granulomatosis with Polyangiitis Presenting as Acute Reversible Cardiomyopathy: A Case Report

Authors

• Stephanie Ammari, HCA Houston Healthcare Clear Lake / University of Houston College of Medicine, Houston, Texas, USA
• Nawras Ibrahim, HCA Houston Healthcare Clear Lake / University of Houston College of Medicine, Houston, Texas, USAFollow
• Bahaeddin Shabaneh, HCA Houston Healthcare Clear Lake / University of Houston College of Medicine, Houston, Texas, USA

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare ANCA-associated vasculitis characterized by asthma, eosinophilia, and small-vessel vasculitis. Cardiac involvement occurs in up to 62% of cases but is more commonly associated with ANCA-negative disease; MPO-ANCA positivity typically correlates with vasculitic manifestations such as neuropathy and glomerulonephritis rather than isolated cardiomyopathy. We present a 65-year-old man with adult-onset asthma who developed acute dyspnea, markedly elevated high-sensitivity troponin (peak 1980 ng/L), peripheral eosinophilia (peak 1550/mm³), and new left ventricular systolic dysfunction (LVEF 30–34%) with normal coronary angiography. He improved rapidly after intravenous corticosteroids, with LVEF normalization to 55–60% within six weeks. MPO-ANCA was positive (6.0 U; normal

Recommended Citation

Ammari, Stephanie; Ibrahim, Nawras; and Shabaneh, Bahaeddin (2026) "MPO-ANCA–Positive Eosinophilic Granulomatosis with Polyangiitis Presenting as Acute Reversible Cardiomyopathy: A Case Report," Journal of Community Hospital Internal Medicine Perspectives: Vol. 16: Iss. 5, Article 17.
DOI: https://doi.org/10.55729/2000-9666.1636
Available at: https://scholarlycommons.gbmc.org/jchimp/vol16/iss5/17

DOI

10.55729/2000-9666.1636