Extranodal Marginal Zone Lymphoma of the Breast in a Patient with Chronic Hepatitis C Infection: A Case Report

Authors

• Ravneet K Dhanoa, MedStar Union Memorial Hospital, Baltimore, USA
• Bipasha Goyal, Government Medical College and Hospital, Chandigarh, IndiaFollow
• Prateek Jain, All India Institute of Medical Sciences, Rishikesh, India
• Marilyn Baird-Howell, MedStar Franklin Square Medical Center, Baltimore, USA
• Mounika Gangireddy, MedStar Franklin Square Medical Center, Baltimore, USA

Abstract

Primary breast lymphomas account for less than 1% of all non-Hodgkin lymphomas and 0.04–0.5% of all malignant breast neoplasms. We report a case of breast extranodal marginal zone lymphoma (EMZL) in a 60-year-old woman with chronic hepatitis C virus (HCV) infection. After comprehensive evaluation excluded other known etiologies, chronic HCV infection emerged as the most plausible contributing factor. Epidemiologic and biological evidence supports an association between HCV and B-cell non-Hodgkin lymphomas, particularly marginal zone lymphomas. Our case adds to the limited literature suggesting that HCV should be considered as a potential etiological factor in breast EMZL. We discuss the emerging role of direct-acting antiviral (DAA) therapy in HCV-associated indolent lymphomas and its implications for management.

Recommended Citation

Dhanoa, Ravneet K; Goyal, Bipasha; Jain, Prateek; Baird-Howell, Marilyn; and Gangireddy, Mounika (2026) "Extranodal Marginal Zone Lymphoma of the Breast in a Patient with Chronic Hepatitis C Infection: A Case Report," Journal of Community Hospital Internal Medicine Perspectives: Vol. 16: Iss. 4, Article 14.
DOI: https://doi.org/10.55729/2000-9666.1619
Available at: https://scholarlycommons.gbmc.org/jchimp/vol16/iss4/14

DOI

10.55729/2000-9666.1619