Losartan-Induced Angioedema: A Case Report and Review of Literature

Authors

Leila C. Tou, Department of Internal Medicine; Wright State University Boonshoft School of Medicine, Dayton, Ohio, USAFollow
Audrey Nourse, Department of Internal Medicine; Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA
Rachel Cox, Department of Internal Medicine; Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA
Spencer Stanford, Department of Internal Medicine; Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA

Abstract

Angiotensin receptor blockers (ARBs) are frequently prescribed as alternatives to angiotensin-converting enzyme inhibitors (ACEIs), particularly in patients who experience ACEI-induced adverse effects including cough. Although ARBs are associated with a lower incidence of angioedema, rare cases have been reported in patients without prior ACEI exposure. Here, we describe a 58-year-old Black male who developed lip and facial swelling six months after starting losartan. His symptoms did not improve with antihistamines or corticosteroids but resolved after discontinuation of losartan, which was replaced with amlodipine without recurrence. This case emphasizes the need for clinician awareness of ARB-induced angioedema and the importance of balancing this rare risk against the established cardiovascular and renal benefits of ARB therapy.

Recommended Citation

Tou, Leila C.; Nourse, Audrey; Cox, Rachel; and Stanford, Spencer () "Losartan-Induced Angioedema: A Case Report and Review of Literature," Journal of Community Hospital Internal Medicine Perspectives: Vol. 16: Iss. 1, Article 8.
DOI: 10.55729/2000-9666.1571
Available at: https://scholarlycommons.gbmc.org/jchimp/vol16/iss1/8

DOI

10.55729/2000-9666.1571