Abstract
Intussusception is predominantly a pediatric condition, with only about 5% of all intussusception cases occurring in adults with primary intestinal lymphomas comprising 1%–4% of gastrointestinal malignancies, 90% of which are B-cell non-Hodgkin lymphomas (NHL). Diffuse large B-cell lymphoma (DLBCL), the most common subtype of NHL, often leads to intussusception without classical B symptoms. We present the case of a 33-year-old male with ileocolonic intussusception caused by a 4.8 × 5.3 × 5.5 cm enhancing mass. Histopathology and FISH confirmed DLBCL without MYC, BCL2, or BCL6 rearrangements, ruling out double- or triple-hit lymphoma. Following a right ileo-colectomy, R-CHOP(rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy was initiated. This case underscores the role of malignancy in intussusception and highlights the importance of timely diagnosis and management.
Recommended Citation
Harisinghani, Komal; Adrejiya, Parth; Abubaker, Mohammad; Idenyi, Oluchi; Babayeuski, Raman; Qureshi, Noor; Kanugula, Ashok; Assaf, Sara; Assaf, Daniel; and Maddika, Srikanth
()
"Hidden Malignancy: Ileocecal Intussusception as an Atypical First Presentation of Diffuse Large B-Cell Lymphoma in Adulthood,"
Journal of Community Hospital Internal Medicine Perspectives: Vol. 16:
Iss.
1, Article 10.
DOI: 10.55729/2000-9666.1567
Available at:
https://scholarlycommons.gbmc.org/jchimp/vol16/iss1/10
DOI
10.55729/2000-9666.1567
