Diagnosis of adrenocortical carcinoma with hypercortisolism in a patient presenting with hypokalemic metabolic alkalosis

Authors

Omair Khan, Maimonides Medical Center
Sheharyar Raashid, Isolation hospital and infection treatment
Muhammad Hashim, Shifa International HospitalFollow
Kevin Clements, Maimonides Medical Center
Sanjay Maheshwari, Maimonides Medical Center
Syed Mohammad Mazhar Uddin, Maimonides Medical Center
Pranay Siriya, Maimonides Medical Center
Aftab Vadsariya, Maimonides Medical Center
Patricia Park, Maimonides Medical Center
William Pascal, Maimonides Medical Center

Abstract

Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of 0.7-2 cases per million. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC are diagnosed incidentally. A careful history, physical exam, and pertinent lab investigations are necessary to reach the diagnosis. Surgical resection is the cornerstone of treatment in localized ACC; however, systemic chemotherapy with mitotane is preferred in patients with widespread disease or those who are not ideal candidates for surgery.

Recommended Citation

Khan, Omair; Raashid, Sheharyar; Hashim, Muhammad; Clements, Kevin; Maheshwari, Sanjay; Uddin, Syed Mohammad Mazhar; Siriya, Pranay; Vadsariya, Aftab; Park, Patricia; and Pascal, William (2022) "Diagnosis of adrenocortical carcinoma with hypercortisolism in a patient presenting with hypokalemic metabolic alkalosis," Journal of Community Hospital Internal Medicine Perspectives: Vol. 12: Iss. 5, Article 23.
DOI: 10.55729/2000-9666.1108
Available at: https://scholarlycommons.gbmc.org/jchimp/vol12/iss5/23