Successful Use of Photodynamic Therapy in a Patients with Squamous Cell Carcinoma of the Lung and Diffuse Endobronchial Lesions

Authors

Ghanshyam Mudigonda, Department of Internal Medicine, Louisiana State University Health Sciences Center
Udhayvir Grewal, Department of Internal Medicine, Louisiana State University Health Sciences Center
David Chambers, Department of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Kavitha Beedupalli, Department of Hematology and Oncology, Louisiana State University Health Sciences Center, Shreveport, LA, USAFollow

Abstract

Field cancerization, a phenomenon in which multiple tumors arise in a carcinogen damaged field could potentially explain the synchronous and metachronous premalignant or malignant lesions surrounding the primary tumor in smokers with aerodigestive malignancies. We report the case of a patient with invasive squamous cell carcinoma (SqCC) of the lung, complicated by multiple synchronous, radiologically silent endobronchial lesions. He underwent successful treatment with stereotactic body radiation therapy (SBRT) followed by adjuvant photodynamic therapy (PDT). We wish to highlight the need for more prospective clinical studies to determine which patient population would be appropriate for early bronchoscopic evaluation and the efficacy of using multimodal therapies like PDT for field cancerization. Further studies could not only give clinicians the opportunity to diagnose radiologically silent endobronchial lesions, but could also lead to using multimodal therapies .

Recommended Citation

Mudigonda, Ghanshyam; Grewal, Udhayvir; Chambers, David; and Beedupalli, Kavitha (2022) "Successful Use of Photodynamic Therapy in a Patients with Squamous Cell Carcinoma of the Lung and Diffuse Endobronchial Lesions," Journal of Community Hospital Internal Medicine Perspectives: Vol. 12: Iss. 4, Article 18.
DOI: 10.55729/2000-9666.1079
Available at: https://scholarlycommons.gbmc.org/jchimp/vol12/iss4/18