Immunoprofile of the adenomatoid odontogenic tumor

Authors

P A. Reichart
H P. Philipsen
P Khongkhunthian
James Sciubba, Greater Baltimore Medical Center (GBMC)

Document Type

Article

Publication Title

Oral Diseases

Abstract

This study was focused on the immunohistochemical profile of the adenomatoid odontogenic tumor. A Pub/Medline search revealed a number of immunohistochemical studies including cytokeratin profiles, extracellular matrix proteins, Integrins, ameloblast-associated proteins resorption regulators (RANK, RANKL), p53, PCNA, MDM2 protein, cyclin D1, Ki-67, Bcl-2 metallothionein, metalloproteinases, D56 hepatocyte growth factor, c-met, DNA methyltransferase, podoplanin, TGF-βI, Smad-2/3, Smad-I-5/-8, Smad 4, beta- catenin, calretinin, and clonality. Careful interpretation of the findings indicates that the adenomatoid odontogenic tumor may be more of a hamartomatous than neoplastic nature.

First Page

731

Last Page

736

DOI

https://doi.org/10.1111/odi.12572

Publication Date

Fall 9-2017

Recommended Citation

Reichart PA, Philipsen HP, Khongkhunthian P, Sciubba JJ. Immunoprofile of the adenomatoid odontogenic tumor. Oral Dis. 2017 Sep;23(6):731-736. doi: 10.1111/odi.12572. Epub 2016 Sep 13. PMID: 27541702.