Insulin Therapy for Acute Pancreatitis in a Patient with Lipase Maturation Factor 1 Mutation: A Case Report

Authors

Neha Bhaskar, Department of Medicine, Division of General Internal Medicine, University of Tennessee Health Science Center, Memphis, TN, USAFollow
Aram Bejnood, Department of Medicine, Division of General Internal Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
Christopher D. Jackson, Department of Medicine, Division of General Internal Medicine, University of Tennessee Health Science Center, Memphis, TN, USA

Abstract

Acute pancreatitis is a frequent cause of hospital admission, managed with intravenous (IV) fluids, analgesia, and oral feeding when tolerated. In patients with hypertriglyceridemia-induced pancreatitis, insulin and other therapies may be necessary for disease resolution. We present a case of a patient with severe acute pancreatitis and euglycemic diabetic ketoacidosis (DKA) with known lipase maturation factor 1 (LMF1) gene mutations, which can impact insulin efficacy on triglyceride metabolism through altered lipoprotein lipase activity, successfully treated with intravenous insulin. This case highlights the effectiveness of insulin therapy even in those with LMF1 gene mutations.

Recommended Citation

Bhaskar, Neha; Bejnood, Aram; and Jackson, Christopher D. () "Insulin Therapy for Acute Pancreatitis in a Patient with Lipase Maturation Factor 1 Mutation: A Case Report," Journal of Community Hospital Internal Medicine Perspectives: Vol. 15: Iss. 1, Article 13.
DOI: 10.55729/2000-9666.1431
Available at: https://scholarlycommons.gbmc.org/jchimp/vol15/iss1/13