A rare case of ANCA-Negative Rapidly Progressive Glomerulonephritis

Authors

Jerry Kenmoe, Department of Internal Medicine, McLaren Health Care/Michigan State University, Flint, Michigan, USAFollow
Elizabeth Mikhail, Department of Internal Medicine, McLaren Health Care/Michigan State University, Flint, Michigan, USA
Fahimeh Talaei, Department of Internal Medicine, McLaren Health Care/Michigan State University, Flint, Michigan, USA
Arvind Kunadi, Department of Nephrology, McLaren Health Care/Michigan State University, Flint, Michigan, USA

Abstract

ANCA-negative rapidly progressive glomerulonephritis (RPGN) is a rare condition caused by glomerular injury in the absence of detectable antineutrophil cytoplasmic antibodies (ANCAs). While comprehensive epidemiologic data is limited, ANCAnegative RPGN is known to comprise 5-20% of all glomerulonephritis cases. We report the case of a 43-year-old male who presented to the hospital after a snowmobile accident with symptoms of general malaise along with the emergence of a new-onset rash and tea-colored urine. Further workup with CT-guided kidney biopsy confirmed the diagnosis of RPGN by revealing histopathological findings of crescentic glomerulonephritis and significant glomerular inflammation. Treatment was promptly initiated with prednisone and Cytoxan and the patient was subsequently discharged in stable condition. We aim to enrich the existing literature by describing the clinical presentation, diagnostic workup and management of ANCA-negative RPGN.

Recommended Citation

Kenmoe, Jerry; Mikhail, Elizabeth; Talaei, Fahimeh; and Kunadi, Arvind (2024) "A rare case of ANCA-Negative Rapidly Progressive Glomerulonephritis," Journal of Community Hospital Internal Medicine Perspectives: Vol. 14: Iss. 4, Article 16.
DOI: 10.55729/2000-9666.1371
Available at: https://scholarlycommons.gbmc.org/jchimp/vol14/iss4/16