Abstract
Pernicious anemia, resulting from Vitamin B12 deficiency and autoimmune processes affecting intrinsic factor production, presents challenges in early diagnosis due to vague initial symptoms. This case report introduces a unique occurrence of pernicious anemia-induced peripheral neuropathy in a patient with concurrent HLA-B27 arthropathy, highlighting the complex interplay of autoimmune mechanisms. While HLA-B27 is not typically associated with pernicious anemia, the case underscores the importance of exploring specific HLA haplotypes in understanding the nuanced manifestation of autoimmune disorders. Comprehensive screening for anti-intrinsic factor and anti-parietal cell antibodies is crucial in individuals with signs of pernicious anemia, especially those with a history of HLA-B27 arthropathy, guiding tailored management strategies. This report contributes to the ongoing exploration of the intricate autoimmune landscape in pernicious anemia.
Recommended Citation
Auda, Auda H.; Atoot, Rami; Jurri, Mohammad; Mahmoud, Ashraf; Siddiqui, Aman; Bangolo, Ayrton; Malik, Tayyab; Sotiriadis, John; and Baker, Iyad
(2024)
"An Uncommon Association: HLA-B27 Positivity in Conjunction with Pernicious Anemia - A Case Report and Literature Review,"
Journal of Community Hospital Internal Medicine Perspectives: Vol. 14:
Iss.
3, Article 8.
DOI: 10.55729/2000-9666.1340
Available at:
https://scholarlycommons.gbmc.org/jchimp/vol14/iss3/8
