Diagnosis of adrenocortical carcinoma with hypercortisolism in a patient presenting with hypokalemic metabolic alkalosis
Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of 0.7-2 cases per million. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC are diagnosed incidentally. A careful history, physical exam, and pertinent lab investigations are necessary to reach the diagnosis. Surgical resection is the cornerstone of treatment in localized ACC; however, systemic chemotherapy with mitotane is preferred in patients with widespread disease or those who are not ideal candidates for surgery.
Khan, Omair; Raashid, Sheharyar; Hashim, Muhammad; Clements, Kevin; Maheshwari, Sanjay; Uddin, Syed Mohammad Mazhar; Siriya, Pranay; Vadsariya, Aftab; Park, Patricia; and Pascal, William
"Diagnosis of adrenocortical carcinoma with hypercortisolism in a patient presenting with hypokalemic metabolic alkalosis,"
Journal of Community Hospital Internal Medicine Perspectives: Vol. 12:
5, Article 23.
Available at: https://scholarlycommons.gbmc.org/jchimp/vol12/iss5/23