Multisystem inflammatory syndrome is a life-threatening condition associated with elevated inflammatory markers and multiple organ injury. A diagnosis of exclusion, it has been reported after severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) in children and adults; recently it has been described in some post-COVID-19 vaccinated individuals. The prognosis with supportive care and immunomodulatory therapy is good, although some individuals may require treatment in the intensive care unit (ICU). Here we report a case of a 58-year-old man who developed multi-organ failure after receiving the second dose of the Moderna mRNA-1273 COVID-19 vaccine. He required critical organ support in the ICU. An extensive workup was done to rule out alternative infectious and inflammatory processes. Following a period of gradual in-hospital convalescence, our patient made a full recovery. To our knowledge, this is the first comprehensively described case of multisystem inflammatory syndrome associated with Moderna mRNA-1273 COVID-19 vaccine in an adult over 50 years of age.
Brown, Meghan; Garbajs, Nika Zorko; Zec, Simon; Mushtaq, Hisham; Khedr, Anwar; Jama, Abbas Bashir; Rauf, Ibtisam; Mir, Mikael; Korsapati, Aishwarya Reddy; Jain, Shikha; Koritala, Thoyaja; Adhikari, Ramesh; Lal, Amos; Gajic, Ognjen; Domecq, Juan Pablo; Goksoy, Sarah; Bartlett, Brian; Sharma, Amit; Jain, Nitesh Kumar; and Khan, Syed Anjum
"A Case of Adult Multisystem Inflammatory Syndrome Following COVID-19 Vaccine,"
Journal of Community Hospital Internal Medicine Perspectives: Vol. 12:
4, Article 2.
Available at: https://scholarlycommons.gbmc.org/jchimp/vol12/iss4/2
Critical Care Commons, Immune System Diseases Commons, Infectious Disease Commons, Internal Medicine Commons, Other Medical Specialties Commons, Other Public Health Commons, Preventive Medicine Commons, Virus Diseases Commons