Investigating The Role of Inflammatory Markers at Admission in Defining the Severity of Moderate-to-Critical COVID-19: A Cross-Sectional Analysis

Authors

Syed Muhammad Jawad Zaidi, House Officer, Department of Medicine, Rawalpindi Medical University 46000, Rawalpindi Pakistan.Follow
Muhammad Haider Awan, House Officer, Department of Medicine, Benazir Bhutto Hospital, 46000, Rawalpindi Pakistan
Hamza Waqar Bhatti, House Officer, Department of Medicine, Benazir Bhutto Hospital, 46000, Rawalpindi Pakistan
Sania Sabir, Post Graduate Trainee, Department of Medicine, Benazir Bhutto Hospital, 46000, Rawalpindi Pakistan
Imran Arshad, Senior Registrar, Department of Medicine, Benazir Bhutto Hospital, 46000, Rawalpindi Pakistan
Sualeha ahmed, Senior Registrar, Department of Medicine, Benazir Bhutto Hospital, 46000, Rawalpindi Pakistan
Muhammad Ali Khalid, Professor of Medicine, Department of Medicine, Benazir Bhutto Hospital, 46000, Rawalpindi Pakistan
Fazal ur Rehman, Professor of Medicine, Department of Medicine, Benazir Bhutto Hospital, 46000, Rawalpindi Pakistan

Abstract

Background and Aims: The spectrum of Coronavirus disease-2019 (COVID-19) has been clinically defined from asymptomatic carriers to critical illness. Different inflammatory markers have been used to account for the severity and outcomes of this disease in different settings. Our study aims to investigate the role of these inflammatory markers in defining COVID-19 severity. Methods: This cross-sectional study included 200 confirmed cases of COVID-19. Inflammatory markers including lymphocyte count, D-Dimers, Ferritin, CRP, LDH were noted at admission. The moderate-to-critical disease was defined according to the WHO criteria. Descriptive statistics were applied. Mann-Whitney U-test was applied to compare the difference of markers between moderate-severe and critical patients. ROC was plotted to determine the cut-off values of these markers. Binary logistics regression analysis was used to assess which markers significantly predict the severity of COVID-19. Results: A D-dimer value of > 775 ng/ml and LDH > 495 U/L had a sensitivity of 72.9% and 79.2% and specificity of 57.9% and 53.6% respectively for critical COVID-19 illness. CRP levels of > 100.5 mg/dl has a sensitivity of 66.7%. All inflammatory markers were significantly higher in a critical group of patients (p

Recommended Citation

Jawad Zaidi, Syed Muhammad; Awan, Muhammad Haider; Bhatti, Hamza Waqar; Sabir, Sania; Arshad, Imran; ahmed, Sualeha; Khalid, Muhammad Ali; and Rehman, Fazal ur (2022) "Investigating The Role of Inflammatory Markers at Admission in Defining the Severity of Moderate-to-Critical COVID-19: A Cross-Sectional Analysis," Journal of Community Hospital Internal Medicine Perspectives: Vol. 12: Iss. 2, Article 1.
DOI: 10.55729/2000-9666.1029
Available at: https://scholarlycommons.gbmc.org/jchimp/vol12/iss2/1