Title
Hydralazine-induced pauci-immune glomerulonephritis: intriguing case series with misleading diagnoses
Document Type
Article
Publication Title
Journal of Community Hospital Internal Medicine Perspectives
Abstract
Hydralazine has been used since the 1950s for the management of hypertension. Evidence for hydralazine-associated vasculitis dates to pre-ANCA (antineutrophil cytoplasmic antibodies) era. This abstract describes two cases of ANCA-positive pauci-immune glomerulonephritis (GN) in challenging scenarios where diagnosis was misconstrued. A comprehensive literature review was done to understand the pathogenesis of drug-induced pauci-immune GN. We have described key diagnostic features that are helpful in distinguishing idiopathic ANCA vasculitis from drug-induced vasculitis. Additionally, we have also described different treatments meant to provide therapy options with the least side effects.
DOI
https://doi.org/10.3402/jchimp.v6.30632
Publication Date
Spring 4-25-2016
Recommended Citation
Babar F, Posner JN, Obah EA. Hydralazine-induced pauci-immune glomerulonephritis: intriguing case series with misleading diagnoses. J Community Hosp Intern Med Perspect. 2016 Apr 25;6(2):30632. doi: 10.3402/jchimp.v6.30632. PMID: 27124161; PMCID: PMC4848433.