An unusual case of chronic lymphocytic leukemia, multiple myeloma and cardiac amyloidosis
Journal of Community Hospital Internal Medicine Perspectives
Light chain amyloidosis has very rarely been reported in association with chronic lymphocytic leukemia (CLL). We reported on a 76-years-old female who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted multiple myeloma with plasma cells causing AL amyloidosis involving the heart. While monoclonal immunoglobulins occasionallyproduced by CLL have previously been implicated in AL amyloidosis, there only a few cases reported of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL.
Liu D, Uqdah HT, Gordy AD. An unusual case of chronic lymphocytic leukemia, multiple myeloma and cardiac amyloidosis. J Community Hosp Intern Med Perspect. 2017 Sep 19;7(4):230-233. doi: 10.1080/20009666.2017.1370940. PMID: 29046749; PMCID: PMC5637643.